Methods Development
A selection of methodological interests and recent publications
High-dimensional mediation analysis
How to quantify omics mediators in the path from an environmental exposure to a trait?
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2026
Estimation of total mediation effect for a binary trait in a case-control study for high-dimensional omics mediators
Annals of Applied Statistics (In press)
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2025
Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting
Biostatistics, 26(1), kxae037
Multi-omics integrative analysis
How to improve causal gene discovery for diseaases, including rare childhood cancer?
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2026
A Pseudotime-Dependent TWAS Framework Identifies Disease Genes along Cell Developmental Paths
HGG Advances, 7(4), 100634
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2025
Multiancestry transcriptome-wide association study identifies candidate genes associated with hepatoblastoma
Cancer Epidemiology, Biomarkers & Prevention, 34(8), 1405-1414.
Gene × environment interaction
How does environment variable influence genetic effects on a trait?
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2020
Incorporating multiple sets of eQTL weights into gene-by-environment interaction analysis to identify novel susceptibility loci for pancreatic cancer
Genetic Epidemiology, 44(8), 880–892